A combined hormonal drug containing estrogen and gestagen.
Estradiol valerate is an estrogen that is converted into natural 17β-estradiol in the human body.
Norgestrel is a derivative of progesterone.
The addition of norgestrel for 10 days of each cycle prevents the development of endometrial hyperplasia and cancer.
Due to the composition and cyclic regimen of this combination (taking only estrogen for 11 days, then a combination of estrogen and gestagen for 10 days, and finally a 7-day break), women with an intact uterus establish a menstrual cycle with regular use of the drug.
While taking this combination, ovulation is not suppressed, and hormone production in the body itself remains virtually unchanged.
Estradiol replenishes the estrogen deficiency in the female body after menopause and provides effective treatment of psychoemotional and vegetative climacteric symptoms (such as hot flashes, increased sweating, sleep disturbances, increased nervous excitability, irritability, palpitations, cardialgia, dizziness, headache, decreased libido, muscle and joint pain); involution of the skin and mucous membranes, especially the mucous membranes of the genitourinary system (urinary incontinence, dryness and irritation of the vaginal mucosa, pain during intercourse).
Estradiol prevents bone loss caused by estrogen deficiency. This is mainly due to the suppression of osteoclast function and a shift in the bone remodeling process towards bone formation. It has been proven that long-term use of hormone replacement therapy (HRT) can reduce the risk of peripheral bone fractures in women after menopause. When HRT is discontinued, the rate of bone loss is comparable to that seen immediately after menopause. There is no evidence that HRT can restore bone mass to pre-menopausal levels.
HRT also has a beneficial effect on collagen content in the skin, as well as on its density, and may also slow down the formation of wrinkles.
HRT leads to a decrease in total cholesterol, LDL and an increase in HDL cholesterol, as well as an increase in triglyceride levels. The progestogen contained in this combination to some extent interferes with the effects of estradiol on lipid metabolism.
