Mode of application
for adults:
inside. The tablet is swallowed whole with a small amount of liquid.
If a woman does not take estrogens or switches to Angeliq from another continuous combination drug, she can start treatment at any time. Patients who switch to Angeliq from a combination drug for cyclic HRT should begin taking after the end of the current cycle of therapy.
Each package is designed for a 28-day intake.
One tablet should be taken daily. After finishing taking 28 tablets from the current package, the next day, start a new package of Angeliq (continuous HRT), taking the first tablet on the same day of the week as the first tablet from the previous package.
The time of day when a woman takes the drug does not matter, however, if she started taking the pills at any particular time, she should stick to this time and beyond. The forgotten tablet must be taken as soon as possible. If more than 24 hours have passed since the usual time of admission, an additional tablet should not be taken. If several tablets are missed, vaginal bleeding may develop.
Indications
– hormone replacement therapy for disorders caused by estrogen deficiency in postmenopausal women with an intact uterus, not earlier than 12 months after the last menstruation;
– prevention of osteoporosis in postmenopausal women with a high risk of fractures, with intolerance or contraindication to the use of other drugs for the prevention of osteoporosis.
Contraindications
Angeliq is contraindicated in the presence of any of the following conditions/diseases. If any of these conditions occur while taking the drug Angeliq, you should immediately stop using the drug:
– pregnancy;
– the period of breastfeeding;
– bleeding from the vagina of unspecified etiology;
– a confirmed or suspected diagnosis of breast cancer or a history of breast cancer;
– a confirmed or suspected diagnosis of a hormone-dependent precancerous disease or a hormone-dependent malignant tumor;
– liver tumors at present or in history (benign or malignant);
– severe liver disease;
– severe kidney disease at present or in history or acute renal failure;
– acute arterial thrombosis or thromboembolism, incl. leading to myocardial infarction, stroke;
– deep vein thrombosis in the acute stage, venous thromboembolism (including pulmonary embolism) at present or in history;
– the presence of a high risk of venous and arterial thrombosis;
– identified hereditary or acquired predisposition to arterial or venous thrombosis, including resistance to activated protein C, antithrombin III deficiency, protein C deficiency, protein S deficiency, hyperhomocysteinemia, antiphospholipid antibodies (cardiolipin antibodies, lupus anticoagulant); conditions preceding thrombosis (transient ischemic attacks, angina pectoris);
– untreated endometrial hyperplasia;
– severe hypertriglyceridemia;
– porphyria;
– children and adolescents up to 18 years;
– congenital lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
– hypersensitivity to the components of the drug Angeliq.
Carefully
Angeliq should be prescribed with caution in the following diseases: arterial hypertension, congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), cholestatic jaundice or cholestatic pruritus during a previous pregnancy, endometriosis, uterine fibroids, otosclerosis, diabetes mellitus.
It should be taken into account that estrogens alone or in combination with gestagens should be used with caution in the following diseases and conditions: the presence of risk factors for the development of thrombosis or thromboembolism and estrogen-dependent tumors in a family history (1st-line relatives with thromboembolic complications at a young age or breast cancer), history of endometrial hyperplasia, smoking, hypercholesterolemia, obesity, systemic lupus erythematosus, dementia, gallbladder disease, retinal vascular thrombosis, moderate hypertriglyceridemia, edema in chronic heart failure, severe hypocalcemia, endometriosis, bronchial asthma, epilepsy, migraine , liver hemangiomas, hyperkalemia, conditions predisposing to the development of hyperkalemia, taking drugs that cause hyperkalemia – potassium-sparing diuretics, potassium preparations, ACE inhibitors, angiotensin II receptor antagonists and heparin
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