Pharmacological action
Synthetic antiandrogen. Similar in chemical structure to natural androgens, has the ability to competitively bind to tissue receptors of these hormones in target organs. Reduces or eliminates the effects of androgens, including those associated with excess production of male sex hormones.
Has gestagenic activity and antigonadotropic properties.
Pharmacokinetics
After oral administration, it is slowly absorbed from the gastrointestinal tract. Cmax in plasma is achieved after 3-4 hours. The final T1 / 2 is about 38 hours.
Cyproterone is metabolized in the liver. The main metabolite 15β-hydroxycyproterone has antiandrogenic activity.
About 35% of the dose is excreted in the urine in the form of free and conjugated metabolites. The remainder is excreted in the feces.
Indications for the active substance CIPROTERONE
For men: correction of pathological deviations in sexual behavior (if it is necessary to reduce sexual activity), metastatic or inoperable prostate cancer (without and after orchiectomy, as well as in combination with GnRH agonists).
For women: moderate androgenic alopecia; moderate hirsutism; severe and moderate acne and/or seborrhea; contraception (as part of combination drugs).
Dosage regimen
Established individually, depending on the indications and treatment regimen.
Contraindications for use
Liver diseases, hereditary benign hyperbilirubinemia (Dubin-Johnson and Rotor syndromes); cachexia (except for patients with prostate carcinoma); severe chronic depression; thromboembolic processes or their history; severe diabetes mellitus complicated by angiopathies; sickle cell anemia; adolescence before completion of puberty; pregnancy, idiopathic jaundice of pregnancy or history of severe pruritus and herpes of pregnancy, lactation period.
Warning: Always consult a doctor before using medications.
