This medicine is hormone replacement therapy (HRT). It contains two different female sex hormones: estrogen and progestin. It is used in postmenopausal women whose last menstrual period (menopause) was at least 1 year ago.
The drug is used for:
Relief of postmenopausal symptoms
During menopause, a woman’s production of her own estrogen decreases. This can cause symptoms such as hot flashes in the face, neck, and chest (called hot flashes).
It relieves these symptoms that occur after menopause. You will only be prescribed the drug if your symptoms significantly affect your daily life.
Experience in treating women over 65 years of age is limited. The medicine should not be used
if the following points apply to you.
If you are unsure whether this is the case, consult your doctor before using the product.
You should not use the medicine if:
You have, have had, or are suspected of having breast cancer.
You have a form of cancer that depends on estrogen to grow, for example. B. Cancer of the uterine mucosa (endometrium) or there is appropriate suspicion.
Vaginal bleeding of unknown cause occurs.
Untreated excessive thickening of the lining of the uterus (endometrial hyperplasia).
You have or have previously had a blood clot in a vein (thrombosis), for example. B. in the legs (deep vein thrombosis) or in the lungs (pulmonary embolism)
You have a bleeding disorder (such as protein C deficiency, protein S deficiency, or antithrombin deficiency)
You have or have ever had a condition caused by blood clots in your arteries, such as: B. Heart attack, stroke, or attacks of chest pain with a feeling of tightness in the chest (angina)
You have or have ever had liver disease and your liver function tests have not yet returned to normal.
You have a rare inherited blood disorder called porphyria.
You are allergic to estradiol, norethisterone acetate, or any other ingredient of this medication.
If any of the above diseases occur for the first time while using the drug, stop treatment immediately and consult a doctor immediately.
Always use this medication exactly as your doctor has told you. If you are unsure, consult your doctor or pharmacist.
Your doctor will try to give you the minimum dose needed to treat your symptoms for the shortest time possible. Please talk to your doctor if you think the effect is too strong or too weak.
The patch should be used twice a week, which means you need to apply a new transdermal patch every 3 or 4 days.
Apply patches continuously (without breaks).
Apply the patch
1 Week
1 day
Day 4
Week 2
1 day
Day 4
Week 3
1 day
Day 4
Week 4
1 day
Day 4
Start of treatment
For women who have never received hormone replacement therapy before, or for women who are switching from continuous combined hormone replacement therapy, treatment can begin on any day.
For women switching from cyclic or continuous sequential hormone replacement therapy, treatment should begin immediately the day after completion of the previous treatment cycle.
Children and young people
Estradiol/norethisterone is not indicated for use in children and adolescents.
Duration of treatment
Your doctor has told you how long you should continue treatment. Please be sure to follow these instructions. Please talk to your doctor in advance if you want to stop treatment early. Your doctor will discuss the need for estrogen treatment with you regularly. This should be done at least once a year.
If you used more than you should
If you have used more than the prescribed number of transdermal patches or you suspect an overdose, you should remove the patch(s) and contact your doctor or pharmacist immediately. Symptoms of overdose may include breast tenderness, metrorrhagia, nausea, vomiting, abdominal pain or bloating, restlessness, irritability, and fluid retention. Symptoms of overdose may also include bloating, depressed mood, fatigue, acne and hirsutism. These symptoms will go away when you remove the patch.
If you forgot to use it
If this occurs, apply a new transdermal patch as soon as possible, unless it is time to apply the next patch according to your normal application schedule. In this case, you should wait and just stick to your normal plan. Never apply two patches at the same time. If you forget the patch, your risk of breakthrough bleeding may increase.
If you are scheduled for surgery
If you are scheduled for surgery, tell the operating doctor that you are using the product.
You may need to stop using the patch 4 to 6 weeks before your scheduled surgery to reduce the risk of thrombosis. Ask your doctor when you can continue use.
If you have any further questions about using this medicine, ask your doctor or pharmacist.
