Pharmacotherapeutic group: Antipsychotic agent (neuroleptic)
pharmachologic effect
An antipsychotic agent, a selective antagonist of dopamine and monoamine receptors, has a high affinity for dopamine D2- and serotonin 5-HT2A- and 5-HT7-receptors (Ki = 0.994, 0.47 and 0.495 nM, respectively). Lurasidone also blocks α2C- and α2A-adrenergic receptors (affinity 10.8 and 40.7 nM, respectively), is a partial agonist of serotonin 5-HT1A receptors with an affinity of 6.38 nM. Lurasidone does not bind to histamine and muscarinic receptors.
The mechanism of action of the minor active metabolite of lurasidone, ID-14283, is the same as that of lurasidone. According to positron emission tomography, the use of lurasidone in the dose range from 9 to 74 mg (from 10 to 80 mg of lurasidone hydrochloride) in healthy volunteers resulted in a dose-dependent decrease in the binding of 11C-raclopride, a dopamine D2/D3 receptor ligand, in the caudate nucleus, shell and ventral striatum. Indications of the active substances of the drug Latuda®
Treatment of schizophrenia; as monotherapy for major depressive episodes due to bipolar affective disorder type I (bipolar depression); as adjunctive therapy with lithium or valproic acid for major depressive episodes due to bipolar affective disorder type I (bipolar depression).Dosing regimen
The method of application and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.
Take orally 1 time / day during meals.
The dose is set individually, depending on the indications, treatment regimen, clinical situation.
Side effect
From the side of the hematopoietic system: rarely – eosinophilia, the frequency is unknown – leukopenia, neutropenia, anemia.
From the side of metabolism: often – an increase in body weight, infrequently – a decrease in appetite, an increase in the concentration of glucose in the blood, hyponatremia.
On the part of the psyche: often – insomnia, agitation, anxiety, anxiety; infrequently – nightmares, catatonia; frequency unknown – suicidal behavior, panic attack, sleep disturbance.
From the nervous system: very often – akathisia, drowsiness, often – parkinsonism, dizziness, dystonia, dyskinesia, infrequently – lethargy, dysarthria, tardive dyskinesia, rarely – neuroleptic malignant syndrome, frequency unknown – convulsions.
From the senses: infrequently – blurred vision, the frequency is unknown – vertigo.
From the side of the cardiovascular system: infrequently – tachycardia, arterial hypertension, arterial hypotension, orthostatic hypotension, “hot flashes”, the frequency is unknown – angina pectoris, AV block I degree, bradycardia.
From the digestive system: often – nausea, vomiting, dyspepsia, hypersalivation, dry mouth, pain in the upper abdomen, discomfort in the stomach, infrequently – flatulence, the frequency is unknown – diarrhea, dysphagia, gastritis.
From the side of the liver and biliary tract: infrequently – an increase in the level of ALT.
From the skin and subcutaneous tissues: infrequently – hyperhidrosis, the frequency is unknown – rash, itching, angioedema, Stevens-Johnson syndrome.
From the immune system: often – hypersensitivity.
From the musculoskeletal system: often – musculoskeletal rigidity, increased concentration of creatine phosphokinase in the blood, infrequently – stiffness in the joints, myalgia, neck pain, back pain, rarely – rhabdomyolysis.
From the side of the kidneys and urinary tract: often – an increase in the concentration of creatinine in the blood, infrequently – dysuria, the frequency is unknown – renal failure.
From the reproductive system: infrequently – an increase in the concentration of prolactin in the blood, the frequency is unknown – breast enlargement, pain in the mammary gland, galactorrhea, erectile dysfunction, amenorrhea, dysmenorrhea.
General reactions: often – fatigue, infrequently – nasopharyngitis, gait disturbance.
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