How does Norvasc work without a prescription?
In professional medical language, Norvasc’s mechanism of action can be explained as follows. Amlodipine is a classic prolonged selective blocker of calcium channels, the exchange of which occurs through special channels in cell membranes. These channels are divided into 6 types, they are located in different organs and tissues.
The drug selectively blocks L-type channels located in the vascular wall, in the myocardium, in the cells of the conducting and contractile systems of the myocardium. Thus, an increase in the concentration of intracellular calcium is blocked, which reduces vascular tone and blood pressure indicators.
The therapeutic effect of amlodipine tablets begins 2-4 hours after ingestion and continues for a full 24 hours.
The degree of absorption of the drug does not depend on the time of intake and the amount of food, as it is slowly absorbed from the gastrointestinal tract. The drug is mainly excreted by the kidneys, but some is excreted in the feces. The half-life is 35 hours.
Buy amlodipine at competitive prices which is used for
Decreased blood pressure (for hypertension)
Symptoms of hypertension are usually absent. The only way to know if you have hypertension is to measure your blood pressure regularly. If high blood pressure is left untreated, it can lead to serious health problems.
Treatment of angina pectoris
Angina pectoris is pain or discomfort in the chest, often radiating to the arms or neck, and sometimes to the shoulders and back. This is pain of cardiac origin, caused by a lack of blood supply to the heart muscle.
However, generic amlodipine Norvasc is not used to relieve a sudden onset of angina pectoris. Your doctor will give you another medicine to help relieve chest pain.
The main pharmacological properties of Norvasc are antianginal and antihypertensive.
In addition to the effects described above, the algae amlodipine also has other properties aimed at preventing diseases of target organs (kidneys, heart, brain), which distinguishes Norvasc from other similar effects:
has a significant anti-sclerotic effect,
reduces the time of natural aggregation of blood platelets
reduces the likelihood of left ventricular hypertrophy
has a cardioprotective effect in ischemic disease
does not affect heart rate
the drug does not affect the metabolism – this allows the drug to be used in patients with gout.
The use of amlodipine (due to the above effects) eliminates such life-threatening complications as atherosclerosis, strokes and heart attacks.
For what diseases can a doctor prescribe amlodipine?
What diseases can Norvasc treat? Amlodipine is used:
for the initial treatment of arterial hypertension
as the only drug to optimize blood pressure in patients
arterial hypertension
stable angina
vasospastic angina
coronary spasm
Dosage of amlodipine
Depending on how effective this medicine is for your condition and how well it is tolerated, your doctor may recommend a dose of 2.5 mg to 10 mg once a day.
The initial dose for the treatment of arterial hypertension and angina pectoris is 5 mg 1 time per day with a gradual increase in dose over 7-14 days to 10 mg / day.
With arterial hypertension, the maintenance dose is 5 mg per day.
With stable angina and vasospastic OP – from 5 to 10 mg 1 time per day.
Dose adjustment is not required when taken simultaneously with thiazide diuretics, beta-blockers and ACE inhibitors.
Dose adjustment is not required only in patients with renal insufficiency.
It is important that this medicine is taken exactly as prescribed by the doctor. If a patient misses an amlodipine dose within 12 hours of their usual dose, they should take Norvasc as soon as possible and return to their usual dosing regimen. If a patient has missed a dose of medication by more than 12 hours and it is almost time for the next dose, they should not take the missed dose and should continue with their usual dosing schedule.
Do not take a double dose to make up for a missed dose. If you don’t know what to do after missing a dose, ask your doctor or pharmacist.
Amlodipine side effects
Amlodipine is relatively well tolerated, in therapeutic doses it does not cause pronounced side effects.
The following side effects have been reported in at least 1% of people taking this drug. The most common side effects of amlodipine include:
dizziness
redness
Headache
nausea
drowsiness
abdominal pain
swelling of the ankles or legs
unusual tiredness or weakness
Although most of the side effects listed below are not very common, they can lead to serious problems if you do not seek medical attention. If you experience any of the following side effects, contact your doctor as soon as possible:
abnormal heart rhythm (eg, fast heartbeat, slow heartbeat, fast heartbeat)
rolling of the head when standing up from a sitting or lying position
increased symptoms of angina (eg, more frequent or severe chest pain)
symptoms of liver problems (eg, nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools).
Some patients may have other unwanted side effects besides those listed. Call your doctor if you experience any symptoms that bother you while you are taking Norvasc.
Contraindication
Amlodipine is contraindicated in the following cases:
hypersensitivity to Norvasc components, especially to dihydropyridine derivatives
active hypotension (eg, systolic blood pressure may be less than 90 mmHg)
acute myocardial infarction (especially the first 28 days)
cardiogenic shock, collapse
unstable angina
left ventricular outflow obstruction
age up to 18 years (do not use in children due to the lack of confirmed data on efficacy and safety).
With caution, the doctor may prescribe Amlodipine for:
liver dysfunction,
sick sinus syndrome (SSS)
arterial hypotension
diabetes
lipid metabolism disorders
aortic stenosis
mitral stenosis
impaired renal function.
Experimental studies on the use of the drug amlodipine at any stage of pregnancy and during breastfeeding have not been conducted, so the drug should be used only when the actual benefit to the mother’s health significantly outweighs the possible risk to the unborn child.
Interaction of amlodipine with other drugs
The drug Norvasc can be used with other pharmaceuticals, but the effect of amlodipine can both increase and decrease.
The effectiveness of the drug is reduced with the simultaneous use of the following drugs:
preparations containing calcium
non-steroidal anti-inflammatory drugs
The effect of amlodipine is enhanced when combined with the following drugs:
drugs that reduce the activity of the production of liver enzymes (may increase the toxic effect of amlodipine and activate its side effects)
diuretics, blockers, ACE inhibitors, nitrates, neuroleptics, amiodarone.
Amlodipine does not interact with cardiac glycosides.
Simultaneous administration of Norvasc with preparations containing lithium significantly increases their toxicity and increases the manifestation of side effects.
Some interactions of amlodipine with specific drugs:
in combination with the drug verapamil enhances the hypotensive and antianginal effects
interactions with indomethacin are not known
Cimetidine is not able to influence the pharmacodynamics of amlodipine.
antiviral ritonavir increases plasma concentrations of calcium channel blockers
Isoflurane enhances the hypotensive effect of the amlodipine-dihydropyridine component.
Buy Norvasc online, this drug is safe to use for the treatment of arterial hypertension in combination with thiazide diuretics, ACE inhibitors and alpha-blockers (beta-blockers, on the contrary, can exacerbate heart failure).
In the treatment of stable angina, amlodipine is combined with similar antianginal drugs, such as nitrates and their derivatives.
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