pharmachologic effect
Antianemic drug, the action of which is due to the properties of the components that make up its composition.
Ferrous sulfate is a salt of iron, a trace element necessary for the synthesis of hemoglobin. Iron is part of hemoglobin, myoglobin and a number of enzymes. When iron is used in the form of salts, its deficiency in the body is quickly replenished, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dry skin) and laboratory symptoms of anemia.
Mucoproteosis provides better tolerability of the drug and increases the bioavailability and gradual release of ferrous iron (Fe2+) from the drug.
Ascorbic acid improves iron absorption.
The special neutral shell of the tablets ensures the absorption of the active ingredients, mainly in the distal small intestine. The absence of a local irritant effect on the gastric mucosa contributes to the good tolerability of the drug from the gastrointestinal tract.
Pharmacokinetics
After taking the drug, iron absorption occurs mainly in the duodenum and in the proximal jejunum. Cmax of iron ions in blood plasma is reached 7 hours after taking the drug and remains elevated during the day. On average, 10-20% of the dose taken is absorbed. Absorption increases with a decrease in iron stores in the body.
The binding of iron to plasma proteins is 90% or more. It is deposited in the form of ferritin or hemosiderin in the cells of the system of phagocytic macrophages, a small amount – in the form of myoglobin in the muscles. Iron is excreted in feces, urine and sweat. Dosing regimen
Adults and children over 6 years of age: tablets are taken orally (without chewing). It is advisable to take the drug with water, before meals or during meals. Use for medicinal purposes: children over 6 years old – 1 tab. / day, children over 10 years old and adults – 1-2 tab. / day.
Prophylactic use: pregnant women – 1 tablet / day or every other day during the last two trimesters of pregnancy (or starting from the 4th month).
Duration of admission
Adult patients should take the drug for a period that provides correction of anemia and restoration of iron reserves in the body. The dose for women is 600 mg, for men – 1200 mg.
With iron deficiency anemia, the duration of administration is from 3 to 6 months, depending on the degree of depletion of the iron reserve: if necessary, in the absence of adequate control of anemia, it is necessary to increase the duration of the drug.
Side effect
From the digestive system: rarely – abdominal pain, nausea, vomiting, diarrhea, constipation.
In some cases, allergic skin reactions are possible. Use during pregnancy and lactation
Prophylactic use: pregnant women – 1 tablet / day or every other day during the last two trimesters of pregnancy (or starting from the 4th month). Use in children
Children over 6 years of age: tablets are taken orally (without chewing). It is advisable to take the drug with water, before meals or during meals. Use for medicinal purposes: children over 6 years old – 1 tab. / day, children over 10 years old – 1-2 tab. / day.
Contraindicated in children under 6 years of age.
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