Inside, during or after meals, or in between meals, with a small amount of liquid.
Long-acting tablets (whole tablet or half, if so prescribed by a doctor) should be taken without chewing.
The drug can be used both as monotherapy and as part of combination therapy.
Since the active substance is released from the extended-release tablets slowly and gradually, they are prescribed 2 times a day.
Considering that Tegretol® CR is prescribed 2 times a day, the doctor determines the optimal therapy regimen based on the recommendations given.
Transfer of a patient from taking Tegretol® in the form of regular tablets to taking Tegretol® CR, prolonged-release tablets
Clinical experience shows that in some patients, when using prolonged-release tablets, it may be necessary to increase the dose of the drug.
Taking into account drug interactions and features of the pharmacokinetics of antiepileptic drugs, doses of the drug should be selected with caution in elderly patients.
Epilepsy
If possible, the drug should be administered as monotherapy.
The drug is usually ineffective in small seizures (petit mal, absence) and myoclonic seizures.
Treatment begins with the use of a small daily dose, which is then slowly increased until the optimal effect is achieved.
To select the optimal dose of the drug, it is recommended to determine the concentration of the active substance in the blood plasma.
When Tegretol® CR is added to other antiepileptic drugs taken, the dose of Tegretol® CR is increased gradually. If necessary, carry out an appropriate correction of the doses of the drugs taken.
For adults, the initial dose of carbamazepine is 100-200 mg 1 or 2 times a day. Then it is slowly increased until the optimal therapeutic effect is achieved; it is usually achieved at a dose of 400 mg 2-3 times a day. Some patients may need to increase the daily dose to 1600 or 2000 mg.
Tegretol® CR, film-coated tablets, should be used in children aged 4 years and older. In children under 3 years of age, Tegretol® is preferably used in the form of a syrup due to the difficulties of using solid dosage forms in this age group. In children over 4 years of age, treatment may be started with 100 mg/day; the dose is increased gradually, by 100 mg per week.
Maintenance doses for children are set at the rate of 10-20 mg / kg / day (in divided doses).
For children aged 4–5 years, the daily dose is 200–400 mg; 6-10 years – 400-600 mg; 11-15 years – 600-1000 mg.
trigeminal neuralgia
The initial dose is 200-400 mg / day. It is slowly increased until the pain disappears (usually 200 mg 3-4 times a day). Then the dose is gradually reduced to the minimum maintenance. The recommended starting dose for elderly patients is 100 mg twice daily.
alcohol withdrawal syndrome
The average dose is 200 mg 3 times a day. In severe cases, during the first few days, the dose may be increased (for example, 400 mg 3 times a day). In severe manifestations of alcohol withdrawal, treatment begins with the use of the drug in combination with drugs that have a sedative and hypnotic effect (for example, clomethiazole, chlordiazepoxide). After the resolution of the acute phase, treatment with the drug can be continued as monotherapy.
Polyuria and polydipsia of neurohormonal nature in diabetes insipidus of central origin
The average dose for adults is 200 mg 2-3 times a day. In children, the dose of the drug should be reduced in accordance with the age and body weight of the child.
Pain in diabetic neuropathy
The average dose is 200 mg 2-4 times a day.
Acute manic states and supportive treatment of affective (bipolar) disorders
The daily dose is 400-1600 mg. The average daily dose is 400-600 mg (in 2-3 doses). In an acute manic state, the dose should be increased fairly quickly. In the maintenance therapy of bipolar disorders, in order to ensure optimal tolerability, each subsequent dose increase should be small, the daily dose should be increased gradually.
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