Pharmacological action
Zolpidem is a hypnotic drug belonging to the imidazopyridine group and is a selective agonist of the omega1-benzodiazepine receptor subclass. It has a sedative effect, but when used in normal doses, it does not have anxiolytic, central muscle relaxant or anticonvulsant effect. It excites benzodiazepine receptors (omega) in the alpha subunit of GABA receptor complexes localized in the area of the IV plate of the sensory-motor zones of the cortex, reticular parts of the substantia nigra, optic thalamus of the ventral thalamic complex, pons, globus pallidus, etc. Interaction with omega receptors leads to the opening of neuronal ionoform channels for chlorine ions.
Shortens the time it takes to fall asleep, reduces the number of night awakenings, increases the total duration of sleep and improves its quality. Lengthens stage II sleep and stages of deep sleep (III and IV). Does not cause drowsiness during the day.
Indications for Zolpidem
sleep disorders: difficulty falling asleep, early and night awakenings.
Contraindications for use
acute and/or severe respiratory failure;
severe acute or chronic liver failure;
sleep apnea (including suspected);
due to the presence of lactose: hereditary lactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;
pregnancy;
lactation period;
childhood (under 18 years);
hypersensitivity to zolpidem or another component of the drug.
With caution: severe myasthenia, respiratory failure, mild to moderate liver failure, depression, alcoholism, drug addiction and other types of addiction.
Warning: Always consult a doctor before using medications.
