Indications for the use of ciprofloxacin
The antibiotic ciprofloxacin is indicated for infectious and inflammatory diseases caused by microorganisms sensitive to ciprofloxacin, including diseases of the respiratory tract, organs of the abdominal cavity and small pelvis, bones, joints, skin; with septicemia; in severe infections of the ENT area, in the treatment of postoperative infections, in the prevention and treatment of infections in patients with reduced immunity.
You can easily and securely buy generic ciprofloxacin on this page of the Lékárna online store. Our pharmacy offers a favorable price for Ciprofloxacin 250/500 mg, confidential shopping and fast delivery. Always read the package insert for ciprofloxacin and if you have any questions about the effect or use of the product, consult your doctor or pharmacist.
Key points of the antibiotic ciprofloxacin
Ciprofloxacin (generic cipro) is a fluoroquinolone antibiotic that interferes with the synthesis of bacterial DNA in susceptible organisms and inhibits the enzymes necessary for bacterial life – DNA gyrase (topoisomerase II) and topoisomerase IV.
It is active against a wide range of Gram-negative bacteria, including Pseudomonas aeruginosa.
The antibiotic ciprofloxacin is one of the few oral drugs effective against Pseudomonas sp.
Ciprofloxacin is NOT considered a “respiratory fluoroquinolone” due to its limited efficacy against Streptococcus pneuamoniae compared to other fluoroquinolones.
Note that ciprofloxacin reaches high concentrations in the lungs.
It is effective against atypical microorganisms such as Legionella sp. and Mycoplasma sp.
Ciprofloxacin in tablet form, when taken orally, binds to cations (eg calcium), so Cipro should not be taken concomitantly with milk, calcium carbonate (may be listed as E 170 in food ingredients) or other substances that can bind to levofloxacin and prevent its absorption .
Dose adjustment is required depending on the degree of renal insufficiency.
Bioavailability 70%
If possible, avoid the use of ciprofloxacin in uncomplicated urinary tract infections, acute sinusitis, or acute bronchitis.
Ciprofloxacin is a commonly prescribed drug for the treatment of prostatitis due to its ability to penetrate the ptostat (and is effective against E. coli).
Ciprofloxacin can be bought at pharmacies under various brand names. In total, more than 100 generic drugs with this active substance are produced in the world.
Indications – what is ciprofloxin generic Cipro used for?
The drug is intended for the effective treatment of many infectious diseases:
Pneumonia, bronchiectasis, pleurisy, lung abscess, pulmonary cystic fibrosis
Salmonellosis, cholera, typhoid fever, dysentery
Cholecystitis, gallbladder empyema, intra-abdominal abscesses
peritonitis and sepsis
Adnexitis, salpingitis, endometritis, prostatitis
Gonorrhea and chlamydia
Osteomyelitis and septic arthritis
Ciprofloxacin can also be prescribed to prevent purulent-inflammatory complications after surgery.
Operating principle
The antibiotic ciprofloxacin actively fights many different pathogens. It has a dual action: inhibits the synthesis (new creation) of proteins and prevents their proliferation. It is effective against such pathogens:
enterobacteria Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp. (including Klebsiella oxytoca), Citrobacter spp., Enterobacter spp.
other Gram-negative bacteria: Proteus vulgaris, Proteus mirabilis, Edwardsiella tarda, Serratia marcescens, Hafnia alvei, Morganella morganii, Providencia spp., Yersinia spp., Vibrio spp., Haemophilus spp., Moraxella catarrhalis, Pseudomonas aeruginosa, Campylobacter jejuni, Neisseria spp. , Aeromonas spp., Plesiomonas shigelloides, Pasteurella multocida.
intracellular pathogens: Legionella pneumophila, Chlamydia trachomatis, Brucella spp., Listeria monocytogenes, Mycobacterium kansasii, Mycobacterium avium-intracellulare, Mycobacterium tuberculosis
Gram-positive aerobic bacteria: Staphylococcus spp. (Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Streptococcus spp. (Streptococcus pyogenes, Streptococcus agalactiae).
Most methicillin-resistant staphylococci are also resistant to ciprofloxacin. Streptococcus pneumoniae, Enterococcus faecalis are moderately sensitive to ciprofloxacin, and Corynebacterium spp., Ureaplasma urealyticum, Bacteroides fragilis, Pseudomonas cepacia, Clostridium difficile, Pseudomonas maltophilia, Nocardia asteroides are completely resistant.5
Dosage of ciprofloxacin
Take Generic Cipro or Ciprofloxacin exactly as directed by your doctor. For the treatment of most infectious diseases, 250 to 500 mg of ciprofloxacin is administered 2 times a day. In complicated pneumonia and severe course of the disease, a single dose is increased to 750 mg. The interval between doses is 12 hours.
In patients with impaired renal function, the dose is halved. In elderly patients, the dose of the drug is reduced to 25-30%.
Side effects
The use of this antibiotic can cause certain adverse reactions due to the individual characteristics of the organism:
Tachycardia, arrhythmia, arterial hypotension
Nausea, vomiting, flatulence, jaundice, hepatic necrosis
Crystals, erythrocytes, protein in urine, glomerulonephritis
Skin itching, photosensitivity, anaphylactic shock
Pain in joints and ligaments, tendinitis
Some side effects may be perceived as symptoms of an underlying disease, such as fatigue, headache, and blood leukocytosis.
Contraindication
Antibiotic ciprofloxacin is contraindicated inside and intravenously:
during pregnancy and breastfeeding
liver and kidney failure
after a stroke
mental disorders
epilepsy and convulsive states.
Information for professionals:
Trade name of the product – Cipro®, Ciplox®
International non-proprietary name INN – Ciprofloxacin
Systematic name 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Pharmacotherapeutic group – Antibiotic, Quinolones/fluoroquinolones
Dosage form – tablets
Medicines containing ciprofloxacin as an active ingredient, as well as the antibiotic Cipro, are dispensed in pharmacies of the Czech Republic by prescription.
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